Professor of Molecular Biosciences at Stockholm University
“The research in my group is focused on functional consequences of adenosine to inosine (A-to-I) RNA editing, the most common type of editing in mammals. We are particularly interested in the function of RNA editing in neurons and in understanding how editing contributes to the variety of the transcriptome during brain development and neuronal stimulation.”
In recent years proofs of the eukaryotic messenger RNA as a target for gene regulation and sequence alteration has vastly expanded. New technologies such as high throughput sequencing of entire transcriptomes have revealed that alternative RNA processing events are used to increase the diversity of the proteome to a much larger extent than previously anticipated.
By alternative splicing, alternative polyadenylation and RNA editing the possibilities to diversify and regulate the RNA population are almost infinite. In addition an increasing number of non-coding RNAs such as microRNAs, have been discovered to contribute to tissue specific and developmentally regulated transcriptome variation.
Next Crosstalks august 20, 6:00 PM CET